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Biosafety studies for electrical parameters, materials and designs

Program: 
R3
Project area: 
R3.1: Biosafety studies for electrical parameters, materials and designs
Project-ID: 
R3.1.1
Project Status: 
Ongoing

Background

Being a chronically implanted device, changes to the cochlear implant require a biosafety assessment before they can be implemented in the device and the clinic.  This project includes a range of studies on the cochlear implant and its electrode array.    

The cochlea is a small and delicate organ, and as such, the introduction of the cochlear implant’s electrode array must be done with as little damage to the structure and function as possible.  Ensuring this safety over the lifetime of the recipient is becoming even more important with the increased implantation of people with residual hearing.  
This project team works closely with engineers and scientists at Cochlear Ltd to enable the knowledge gained to be applied to the device. 

Please contact Dr Carrie Newbold for more information on this project, including queries on potential collaborations and studentships.

Detail

The electrode part of the cochlear implant is located in the 'scala tympani' chamber of the cochlea. A short period after implantation, a dense fibrous tissue sheath usually forms around this electrode.

The fibrous tissue sheath increases electrode impedance, meaning that the size of the electrical stimulus needed to excite the spiral ganglion nerve cells to induce a hearing sensation, needs to be increased. This can lead to voltage compliance problems and ultimately some electrodes on the cochlear implant electrode array may fail.

Electrical stimulation has been shown to lower electrode impedance, perhaps due to a reorganization of the fibrous tissue sheath over the electrode array. Standard clinical practice involves ‘switching on” recipients 2 to 4 weeks after implantation. One study within this project is looking at what happens when you provide electrical stimulation immediately after implantation. This study will look at the changes in electrode impedance and compare them to the fibrous tissue sheath that forms over the array.  If successful, further research will be undertaken to ensure there are no unwanted side effects with the early onset of stimulation.

Project leadership

 

Project Team

Dimitra Stathopoulos, Scott Chambers.